science.org

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This biologist aims to solve the cell’s biggest mystery. Could it help cancer patients, too?

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This unassuming fern has the largest known genome—and no one knows why

Submittedbyiareuniquetoscience

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Communication Breakdown: Faulty messaging between organs could make us old

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13

Traffic noise causes lifelong harm to baby birds

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Striking Amazonian butterfly (Heliconius elevatus) is a result of an ancient hybrid event. Matings between two species are often evolutionary dead ends. This one birthed a new species.

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Novel antibody-drug conjugate found to be efficacious against inflammatory diseases. It is made up of an anti-TNF antibody and a gluococorticoid receptor modulator.

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‘Cold blob’ of Arctic meltwater may be causing European heat waves - Study identifies chain of events linking Arctic warming and extreme European weather

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Through the last 485 million years, narrow environmental and/or geographical niches increase the risk of a species to go extinct - but extinction risk increases significantly by the magnitude of climate change

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Breathing control of vocalization

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Collections are truly priceless

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Brainstem control of vocalization and its coordination with respiration

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Monitoring homeostasis with ultrasound

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Sister chromatid cohesion is mediated by individual cohesin complexes

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CO2 drawdown from weathering is maximized at moderate erosion rates

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1

Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices

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Accounting for the increasing benefits from scarce ecosystems

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Neural dynamics of predictive timing and motor engagement in music listening

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ScienceAdviser: National Science Foundation must abandon a giant telescope

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1

Touch sensation requires the mechanically gated ion channel ELKIN1

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A morphological basis for path-dependent evolution of visual systems

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‘A tough experience.’ Why would a scientist serve as an expert witness?

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The changing nature of groundwater in the global water cycle

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Defective pollen tube tip growth induces neo-polyploid infertility

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Experiencing science

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Retrograde endocannabinoid signaling at inhibitory synapses in vivo

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Knowing the Neanderthal

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The sci-fi future of medical robots is here, and dehydrating the stratosphere to stave off climate change

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Large-scale self-organization in dry turbulent atmospheres

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2

The “abortion imaginary”: Shared perceptions and personal representations among everyday Americans

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Stat5 induces androgen receptor (AR) gene transcription in prostate cancer and offers a druggable pathway to target AR signaling

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Modulating tumoral exosomes and fibroblast phenotype using nanoliposomes augments cancer immunotherapy

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Chemical and genetic basis of orange flavor

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ScienceAdviser: The scent of female mice shortens the lives of males

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Considering intentional stratospheric dehydration for climate benefits

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Tinkering with fungus genes can turn blue cheeses red, green, or white | Scientists discover how Gorgonzola and Roquefort get their color—and how to change it

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Revolutionary brain stimulation technique shows promise for treating brain disorders

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Monoclonal antibody neutralizes deadly snakebite toxins (e.g. from mambas, cobras). The antibody conferred protection against envenoming in mice through mimicking the binding between the toxins and their receptors.

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Long-lasting plasticity from patterned ultrasound-induced brainwave entrainment

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Homogeneous crystallization and buried interface passivation for perovskite tandem solar modules

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What makes snakes so special, and how space science can serve all

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Achieving sub-0.5-angstrom–resolution ptychography in an uncorrected electron microscope

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Explaining quantum field theory

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Celebrating the immigrant scientist: Meet the 2024 Vilcek Foundation Prize winners

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Arctic sea ice retreat fuels boreal forest advance

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A deadly viral illness is exploding in West Africa. Researchers are scrambling to figure out why

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Chemistry-albedo feedbacks offset up to a third of forestation’s CO2 removal benefits

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Recording physiological history of cells with chemical labeling

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The sociopolitical in human genetics education

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1

Forestation is not an easy fix

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Emission lines due to ionizing radiation from a compact object in the remnant of Supernova 1987A

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Overcoming the noise in neural computing

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Research needs for loss and damage

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Metrics and their misapplications

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Synthesis reveals approximately balanced biotic differentiation and homogenization

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Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

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Disparate processing of numerosity and associated continuous magnitudes in rats

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Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales

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2

Americans increasingly believe Artificial General Intelligence (AGI) is possible to build. They are less likely to agree an AGI should have the same rights as a human being.

theseedsofscience.org

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Society for Science Fuels Innovation with $110K in Educator Grants, Transforming Classrooms for Student STEM Research

societyforscience.org

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2

Women make up two-thirds of people with Alzheimer’s disease and early menopause is a risk factor. A new study in mice shows that activation of a brain protein called CYP46A1 could protect women from developing Alzheimer’s disease. CYP46A1 can be activated by low doses of the anti-HIV drug Efavirenz.

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The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity

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The skin of blueberries does not contain blue pigments; the blue color comes from the microscopic structure of the skin, which scatters blue light more than other wavelengths.

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ATR blocks telomerase from converting DNA breaks into telomeres

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Decoding the autoantibody reactome

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Protons are the new first responders

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Telomerase misbehaves after a breakup

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Conflation of reforestation with restoration is widespread

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Magnetic robotic catheter devised to efficiently treat ischemic strokes | The cutting-edge device with helical surface and rotational motion can navigate the vascular system efficiently, targeting diseased blood vessels with precision.

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Facet-dependent dispersion and aggregation of aqueous hematite nanoparticles

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70th anniversary President’s message

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Celebrating seven decades of the home of Australian science

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Science communication at scale

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Strange wall of stones found beneath Baltic Sea may have helped humans hunt reindeer

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At night, pollution keeps pollinating insects from smelling the flowers

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Oxygen isotope ensemble reveals Earth’s seawater, temperature, and carbon cycle history

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Lineage-specific intolerance to oncogenic drivers restricts histological transformation

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Corpora cavernosa fibroblasts mediate penile erection

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Stabilizing 3D-printed metal alloys

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Escarpment evolution drives the diversification of the Madagascar flora

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Transforming lung cancer types

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Teach Indigenous knowledge alongside science

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Thermography of the superfluid transition in a strongly interacting Fermi gas

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Time for growth

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What drives poor quality of care for child diarrhea? Experimental evidence from India

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Real-time in vivo monitoring of intraocular pressure distribution in the anterior chamber and vitreous chamber for diagnosis of glaucoma

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Broadband and large-aperture metasurface edge encoders for incoherent infrared radiation

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Addressing climate change with behavioral science: A global intervention tournament in 63 countries

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In a research paper published this week, scientists have created the first photonic quantum computer able to perform calculations and error correction using only a few 'qumodes'. Using this they achieve the same computing power as hundreds of qubits.

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2

Grounded language acquisition through the eyes and ears of a single child

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PPML-Omics: A privacy-preserving federated machine learning method protects patients’ privacy in omic data

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tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments

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2

Sighting of newborn great white shark ‘unlike anything we had ever seen before’

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2

The Best Way to Keep Elephant Populations Stable Over Time Is to Allow Them to Roam Freely, Scientists Find

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Obelisks: New viruslike entities found in human gut microbes

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Distinct manifold encoding of navigational information in the subiculum and hippocampus

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Rope making in the Aurignacian of Central Europe more than 35,000 years ago

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G3BP1-dependent condensation of translationally inactive viral RNAs antagonizes infection

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Species identification of ivory and bone museum objects using minimally invasive proteomics

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A new study describing a microscopic, algalike fossil dating back more than 1.6 billion years supports the idea that one of the hallmarks of the complex life we see around us—multicellularity— is much older than previously thought.

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1

Zapping ‘red mud’ in plasma turns mine waste into valuable iron - A simple process quickly extracts iron and renders the rest largely benign

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Observation of millihertz-level cooperative Lamb shifts in an optical atomic clock

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Disruption of an ant-plant mutualism shapes interactions between lions and their primary prey

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Accelerated evolution of chosen genes

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Receptor-associated kinases control the lipid provisioning program in plant–fungal symbiosis

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Designing policy for Earth’s urban future

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Deploying blood-based cancer screening

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Water batteries

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Entertaining audacious ideas

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A big-headed problem drives an ecological chain reaction

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Acceleration and transport of relativistic electrons in the jets of the microquasar SS 433

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Changing fitness effects of mutations through long-term bacterial evolution

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The transcription factor ZEB2 drives the formation of age-associated B cells

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Machine learning predicts which rivers, streams, and wetlands the Clean Water Act regulates

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Automated self-optimization, intensification, and scale-up of photocatalysis in flow

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Material conflicts

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How giant ‘water batteries’ could make green power reliable

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Mega droughts experienced across Western North America in recent decades is unprecedented since at least 16th century

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Endogenous retroviruses shape pluripotency specification in mouse embryos

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Lake surface cooling drives littoral-pelagic exchange of dissolved gases

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Separation of photoionization and measurement-induced delays

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Atmospheric rivers over eastern US affected by Pacific/North America pattern

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Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins

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Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium

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Oscillation of type IV pili regulated by the circadian clock in cyanobacterium Synechococcus elongatus PCC7942

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1

Just Bribe Everyone – It's Only the Scientific Record

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Philippines must commit to carbon mitigation

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Whistleblowers flagged 300 scientific papers for retraction. Many journals ghosted them

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A pulsar in a binary with a compact object in the mass gap between neutron stars and black holes

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Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

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2

The global distribution of plants used by humans

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Logical states for fault-tolerant quantum computation with propagating light

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Mystery in the “mass gap”

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Space-tiled colloidal crystals from DNA-forced shape-complementary polyhedra pairing

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Surface deformations of the 6 February 2023 earthquake sequence, eastern Türkiye

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Genetic history of Cambridgeshire before and after the Black Death

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An in situ digital synthesis strategy for the discovery and description of ocean life

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Adapting to disruptions: Managing supply chain resilience through product rerouting

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India’s coal mining plan undermines climate goals

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Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

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Risks from solar-powered groundwater irrigation

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Searching for meaning in a world aflame

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When the CIA met LSD

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Immune damage in Long Covid

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Doubling the life of Cu/ZnO methanol synthesis catalysts via use of Si as a structural promoter to inhibit sintering

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A female woolly mammoth’s lifetime movements end in an ancient Alaskan hunter-gatherer camp

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Single-pixel transmission matrix recovery via two-photon fluorescence

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Predicting success in Cu-catalyzed C–N coupling reactions using data science

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Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing (reddit)

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Envisioning artificial intelligence

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Synthetic dioxygenase reactivity by pairing electrochemical oxygen reduction and water oxidation

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Decoding the language of immunity

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Illusory generalizability of clinical prediction models

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Deterministic reprogramming of neutrophils within tumors

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Comprehensive conservation assessments reveal high extinction risks across Atlantic Forest trees

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2

Pathways toward commercial perovskite/silicon tandem photovoltaics

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Two thousand years of garden urbanism in the Upper Amazon

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Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape

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Global shark fishing mortality still rising despite widespread regulatory change

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Four cold-causing coronaviruses may provide clues to COVID’s future

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Shark kills rise to more than 100 million per year—despite antifinning laws

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The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism

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Controlling intracavity dual-comb soliton motion in a single-fiber laser

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Universal pictures: A lithophane codex helps teenagers with blindness visualize nanoscopic systems

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Clots reveal anomalous elastic behavior of fiber networks

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We may finally know why the world’s largest primate went extinct

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Moderated ionic bonding for water-free recyclable polyelectrolyte complex materials

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High-precision two-dimensional displacement metrology based on matrix metasurface

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RREB1 regulates neuronal proteostasis and the microtubule network

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Nature protection must precede restoration

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The bumpy road to friction control

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Rooting out scientific misconduct

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Practical challenges for precision medicine

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Tectonic plate under Tibet may be splitting in two

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Undepleted direct laser acceleration

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Imaging privacy threats from an ambient light sensor

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The genetic basis of a recent transition to live-bearing in marine snails

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Dopamine regulates attitude toward risk

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Water recycling goes mainstream

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Data-driven hope for the planet

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Balancing risk-return decisions by manipulating the mesofrontal circuits in primates

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Thermodynamically stable plumber’s nightmare structures in block copolymers

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Genetic variants underlying human bisexual behavior are reproductively advantageous (reddit)

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