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Mobile genetic elements can inadvertently suppress bacterial immune systems, research reveals

phys.org
submitted
a year ago
byrss-bot bottoscience

Summary

Research group led by Artem Isaev, the head of the Metagenome Analysis Laboratory at Skoltech, studied one of the first discovered bacterial immune systems, EcoKI. Found that the presence of plasmid DNA in a cell leads to the activation of restriction alleviation, a built-in immune suppression program. The findings helped gain a better understanding of bacterial recombination processes. The cell repairs DNA breaks in the bacterial genome through a process of homologous recombination. This process also requires a special sequence called a Chi site. This document is subject to copyright. No part of this article may be reproduced without the written permission of the author. The content is provided for information purposes only.

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