Pioneer cells reside inside the inner layer that lines the blood vasculature, the so-called endothelium. Molecular cocktail encodes the time and place of blood vessel formation " The cells in the tissue produce an organ-specific set of molecules that encode the instruction how to make a new blood vessel at that particular place and time. Using this technique, we discovered that the vascular patterning is encoded by a distinct set of molecules that can only be sensed by a subset of endothelial cells to promote vessel growth.
